Investigation of the Use of Microencapsulated Sodium Fusidate for Antibacterialwound Dressings

Proceedings of ‏The 3rd International Conference on Applied Research in Engineering, Science and Technology

Year: 2020

DOI:

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Investigation of the Use of Microencapsulated Sodium Fusidate for Antibacterialwound Dressings

R.A.D.N.Rajapakse , T.A.Weerasekara, N. De Silva, U. G. S. Wijayapala, G.K. Nandasiri

 

ABSTRACT: 

This research was done with the aim of investigating the use of microencapsulated Sodium Fusidate to achieve antibacterial property in a textile based wound dressing. The sterile cotton gauze was selected as the substrate and was improved into an antibacterial wound dressing that particularly targets at treating traumatic wounds, by incorporating microcapsules with antibacterial properties into the gauze structure. The process of microencapsulation was carried out via electro-spraying and the microcapsules thus produced contained Sodium Fusidate dissolved in ethanol as the active substance (core) and the Calcium alginate as the wall material (shell). The obtained microcapsules were characterized by FTIR spectrometry and SEM and the results showed that the microcapsules have been produced in the size ranges of 50-200µm, having Sodium Fusidate as the core material. To attach these microcapsules onto the gaze, they were loaded into a 2% solution of Chitosan and the sterile cotton gauze fabric was impregnated in this dispersion. The antibacterial property of samples taken from this treated gauze fabric was tested against both gram-positive and gram-negative bacteria and the samples produced an average inhibition zone with a diameter of 32 mm for gram-positive bacteria Staphylococcus aureus, which is the most common type of bacteria in traumatic wounds.

Keywords: wound healing, wound dressing, traumatic wounds, antibacterial, microencapsulation, electro-spraying.