Tartaric Acid New Synthetic Derivatives Antibacterial Activity against the Phytopathogenic Pseudomonas syringae

Proceedings of ‏The 2nd International Conference on Advanced Research in Science, Engineering, and Technology

Year: 2021

DOI: https://www.doi.org/10.33422/2nd.icarset.2021.03.120

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Tartaric Acid New Synthetic Derivatives Antibacterial Activity against the Phytopathogenic Pseudomonas syringae

Bella G. Babayan, Aram R. Mikaelyan, Nona L. Asatryan Marina A. Melkumyan, Samvel A. Bagdasaryan, Anna M. Grigoryan



Antimicrobial resistance is one of the most pressing issues of our time, according to WHO’s reports over the past several years. And day by day the further aggravation of the mentioned problem is being caused by increase in antibiotic usage values in various scopes of mankind activity. That is why, the search of novel ecologically safe alternatives of classical antibiotic therapy against pathogen microorganisms is very significant direction of research world around. And it is important not only in case of human pathogens, but also for opportunistic pathogenic microorganisms, pathogens of plants and animals that have a significant impact on public health and agriculture.

During this research, 4 new synthetic derivatives of natural antimicrobial compound – tartaric acid, were elaborated at the laboratory of new agrarian pesticides creation and the quality control of National Polytechnic University of Armenia (NPUA). Their biological activity and biodegradation potential were tested on different soil microorganisms, such as like various strains of phytopathogenic Pseudomonas syringae, from The National Collection of Microorganisms of Microbe Depository Centre (MDC), “Armbiotechnology” Scientific & Production Center (SPC), National Academy of Sciences (NAS), Republic of Armenia (RA).According to results, complex salts of tartaric acid are effective as the prospective and a comparably ecologically safe alternative for combating antimicrobial resistance in this plant pathogen P. syringae. Besides, the obtained substances are effective against the other opportunistic pathogenic representatives of same genera, such as like P. aeruginosa and P. fluorescens. Moreover, the mentioned compounds are biodegradable by soil non-pathogenic P. chlororaphis.

Keywords: tartaric acid derivatives, Pseudomonas syringae, antimicrobial resistance, phytopathogen.