Proceedings of the 8th International conference on Research in Engineering, Science and Technology
Prospects for the use of vitamin D3
Bouzid Djihane, Merzouki Samir, and Zerroug Mohamed Mihoub
Pathogenic fungi are now a real problem in several areas, especially the medical and food field due to their powers of contamination and pathogenicity, as well as the resistance to the majority of antifungals drugs that are most of the time fungistatic. So it is necessary to find new powerful and effective antifungals drugs with a fungicidal action on these pathogens. Vitamin D3 were selected for the test of antifungal activity, through its spectrum of biological activity, so the purpose of our study is to prove that vitamin D3 has a powerful fungicide effect towards the identified fungal strains after isolated from different source (plants, soil, bread… etc).The test of antifungal activity shows that vitamin D3 has a powerful effect on the majority of the strains tested at a minimum fungicide concentration MFC C = 100μg/ml and the inhibition zones vary between 9.33 and 25.5 mm including 6mm the diameter of disc.The obtained minimum fungistatic concentration MFCS are between 50 and 12.5μg.ml – 1, and the value of vitamin D3 MFC C is between 50 and 100μg.ml – 1. The MFCC / MFCS = 2 < 4 so vitamin D3 shows a fungicidal effect.So the Vitamin D3 can be proposed as a medical treatment against human pathogenic fungi or natural food preservative in the field of food industry.
Keywords: Vitamin D3, antifungal activity, fungicidal, fungistatic, minimum fungicidal concentration MFC C, minimum fungistatic concentration MFCS